Science: Aspirin can reverse tooth decay and regenerate teeth

Science: Aspirin can reverse tooth decay and regenerate teeth

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Will aspirin also be used in the future to treat dental problems?
Many people take aspirin to treat their headaches, for example. Researchers have now found that aspirin could reverse the effects of tooth decay. As a result of this effect, fewer fillings would be needed in the future and a significant cost reduction in the health system would be possible.

The researchers at Queen’s University Belfast found that taking aspirin can reverse tooth decay. So-called tooth decay is the most common dental disease worldwide. The experts published a press release on the results of their study.

Disadvantages of synthetic fillings
Tooth decay leads to the destruction of the tooth structure, the formation of cavities and the subsequent inflammation of the tooth nerve, which then leads to toothache for those affected, explain the doctors. Tooth decay results in high costs for the health system. Current tooth decay treatment involves fillings in which dentists restore the cavity or hole using a synthetic material. This material does not resemble the natural tooth structure and has to be replaced many times during the life of the tooth, the experts say.

Aspirin can support the regeneration of lost tooth structure
Researchers from Queen’s University Belfast have discovered that aspirin can be an alternative solution to restoring a tooth that has already decayed. The research results will be presented at the British Society for Oral and Dental Research Annual Conference. Aspirin can improve the function of the stem cells present in teeth and thus support self-repair by regenerating the lost tooth structure, the scientists explain.

Aspirin stimulates stem cells in the teeth
In their investigation, the experts combined genomics and novel bioinformatics to identify a drug with properties that stimulates the existing stem cells in the tooth and thus improves the regeneration of the damaged tooth structure. Her attention fell on aspirin. The treatment of stem cells from the teeth with low-dose aspirin significantly increases the mineralization and expression of genes that are responsible for the formation of dentin, the scientists explain. This hard tooth structure is usually damaged by decay, the experts add.

Aspirin to treat dental inflammation?
This novel discovery, coupled with the well-known anti-inflammatory and pain-relieving effects of aspirin, could be a unique solution for combating dental nerve inflammation and pain, the doctors say. At the same time, natural tooth repair is encouraged.

Aspirin is an innovative solution for tooth repair
Aspirin has great potential to change the approach to one of the greatest dental challenges of today, explains author Dr. El Karim. The initial research in the laboratory suggests that aspirin could offer an instant innovative solution that enables teeth to repair themselves, the expert added.

A suitable delivery system is required for further studies
"Our next step will be to develop a suitable delivery system to test drug efficacy in a clinical trial," the authors say. This novel approach could not only increase the long-term survival of the teeth, but could also lead to major savings for the NHS and other health systems worldwide, the scientists explain. (as)

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